Filter holders are typically either in-line or open-face in design.

In-line filter holders have a variety of inlet and outlet connections, and are used in closed filtration systems with either a pressure or vacuum source. In-line filters are ideal for measurement of feed water contamination. They are easy to open and close, and provide a positive, leak-proof seal. Upstream vents, available on some filter holders, allow for the release of trapped gas during liquid filtration.

Open-face holders are typically used to take industrial hygiene samples. These holders are easily attached to personal sampling pumps via tubing, with an open inlet surface for impaction of airborne contamination.